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Natural Medicines says that bitter orange is "possibly unsafe" when taken by mouth as a supplement, and there's not enough evidence to know if it works for weight loss. According to the FDA, there is little evidence that the herb helps except for short-term weight loss.

In a couple of small studies, people who took 7-keto-DHEA -- along with moderate exercise and a reduced-calorie diet -- lost significantly more weight than those who were given a placebo . But Natural Medicines says there still isn't enough reliable evidence to rate how well it works. Guar gum has been studied much more than other fibers for weight loss, and most researchers say it's not effective.
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